Isolation of a Novel Oxygenated Dimer of 3-Methylindole, 5aβ (H), 11aα (H)-12β-Hydroxy-10bβ, 12α-dimethyl-5a, 10b, 11a, 12-tetrahydro-6H-oxazolo-[3,2-a : 4,5-b'] diindole, and Structure Determination of Its Acetylated Derivative
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概要
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A new oxygenated dimer of 3-methylindole was isolated from the reaction mixture obtained by oxygenation of 3-methylindole in the presence of a sterically crowded cobalt catalyst, N, N'-(cis-1,2-cyclohexylene) bis (3-tert-butylsalicylideneaminato) cobalt (II). X-Ray crystal structure determination of its acetylated derivative revealed it to be 6-acetyl-5aβ (H), 11aα (H)-12β-hydroxy-10bβ, 12α-dimethyl-5a, 10b, 11a, 12-tetrahydro-6H-oxazolo [3,2-a : 4,5-b'] diindole, with a novel C_6-C_4N-C_3NO-C_4N-C_6 ring system. Two conformers due to restricted rotation of the acetyl group of the acetylated derivative was observed by temperature-dependent ^1H-nuclear magnetic resonance spectroscopy.
- 公益社団法人日本薬学会の論文
- 1985-05-25
著者
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後藤 正文
Faculty of Pharmaceutical Sciences, Nagoya City University
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酒井 朝也
Faculty of Pharmaceutical Sciences, Nagoya City University
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伊藤 翼
Institute For Molecular Science
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後藤 正文
Faculty Of Pharmaceutical Sciences Kumamoto University
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黒田 良孝
Department Of Chemical Reaction Engineering Faculty Of Pharmaceutical Sciences Nagoya City Universit
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森 鉱次
Faculty Of Pharmaceutical Sciences Nagoya City University
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酒井 朝也
Department Of Chemical Reaction Engineering Faculty Of Pharmaceutical Sciences Nagoya City Universit
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黒田 良孝
Faculty of Pharmaceutical Sciences Nagoya City University
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後藤 正文
Department Of Chemical Reaction Engineering Faculty Of Pharmaceutical Sciences Nagoya City Universit
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