Coordination Chemical Studies on Metalloenzymes. VIII. Reduction of Co (III)-Bovine Carbonic Anhydrase with L-Ascorbic Acid

スポンサーリンク

概要

• 論文の詳細を見る

• Co (III)-bovine carbonic anhydrase was reduced by L-ascorbic acid with recovery of the enzyme activity. The rate determined by following the increase in the absorbance at 640 nm (characteristic absorption of Co (II)-bovine carbonic anhydrase) was completely consistent with that determined from the recovery of the esterase activity. This result indicates that the recovery of the enzyme activity with L-ascorbic acid was caused by the reduction of a cobalt ion in the enzyme from Co (III)-bovine carbonic anhydrase to Co (II)-bovine carbonic anhydrase by L-ascorbic acid. The rate of the reduction of Co (III)-bovine carbonic anhydrase has a first-order dependence on the concentrations of both L-ascorbic acid and Co (III)-bovine carbonic anhydrase, and the rate constant is 3.6-7.2×10^<-1> sec^<-1>M^<-1>.

• 公益社団法人日本薬学会の論文
• 1980-11-25

著者

• 喜谷 喜徳

  Faculty of Pharmaceutical Sciences Nagoya City University

• 廣瀬 順造

  Department Of Food Science And Technology Faculty Of Engineering Fukuyama University

• 廣瀬 順造

  Faculty of Engineering, Department of Food Science and Technology, Fukuyama University

関連論文

• Antineoplastic Activity of Platinum Complexes of trans-(dl)-1,2-Cyclopentanediamine
• 1R,2R-シクロヘキサンジアミンを配位子にもつ四価および二価白金錯体の細胞毒性(発表論文抄録(1993))
• Cytotoxicity of Platinum(IV) and Platinum(II) Complexes Containing 1R, 2R-Cyclohexanediamine as a Ligand
• Syntheses and Antitumor Activities of 1R,2R-Cyclohexanediamine Pt(II) Complexes Containing Dicarboxylates(Medicinal Chemistry,Chemical)
• 溶媒抽出,原子吸光光度法によるヒスタミンの選択的定量
• Preparation and Complex Formation of Cyclic Octapeptides Containing L-Proline Residues with Phenylalanine Methylester Hydrochloride
• Zinc Deficient Bovine Erythrocyte Superoxide Dismutase Has Low Specific Activity
• The Crystal Structure and Absolute Configuration of the Antitumor Platinum Complex tran(OH)-Pt(OH)_2(Malonato)(1R, 2R, -Cyclohexanediamine)
• Studies on Synthesis, Structure, and Antitumor Activity of Pt(II) Complexes Containing 1,2-Diamino-1,2-dideoxy-D-glucitol
• The Measurement of cis-Platin and trans-Platin by Graphite Atomic Absorption Spectrophotometry
• Studies of Copper-Binding Behavior of Copper-Free and Apo-superoxide Dismutase by High-Performance Liquid Chromatography
• Magnetic Circular Dichroic Spectra of Various Adducts of Co (II)-Bovine Carbonic Anhydrase
• Coordination Chemical Studies on Metalloenzymes. VIII. Reduction of Co (III)-Bovine Carbonic Anhydrase with L-Ascorbic Acid
• Coordination Chemical Studies on Metalloenzymes. IV. Kinetic and Thermodynamic Studies of Metal Removal Reaction from Zinc-and Cobalt-Carbonic Anhydrase with Chelating Agents
• 過剰な亜鉛イオンによるカルボキシペプチダ-ゼAの活性阻害作用--タンパク質の立体構造変化の可能性 (生体関連物質と配位化学) -- (金属酵素・金属タンパク質)
• 各種キレ-ト化剤による炭酸脱水酵素からの金属除去反応に対するpHと活性阻害剤の影響
• 高速液体クロマトグラフィ-によるCr(3)の定量
• Studies on Mass Spectrometry of Metal Chelates. II. Mass Spectrometric Investigation of Thiooxine Metal Chelates
• 白金錯体の制がん効果--最近の話題
• 制癌作用を有する白金錯体の化学 (金属と薬理活性)
• 医薬品としての金属錯体"プラチナががんをなおす" (有機金属錯体--広がるその領域)
• 金属含有医薬品開発の現況 (微量元素と生物圏)
• Synthesis and Antitumor Activity of Pt (II) Complexes containing 2,3-Diaminopropanol Isomers
• Synthesis of Pt(II) Complexes Containing D-Glucuronate, D-Gluconate, or Their Acetyl Derivatives and Evaluation of Antitumor Activity against Murine Leukemia L1210
• Synthesis and Antitumor Activity of Riboflavin and Flavin Mononucleotide Pt(II) Complexes
• Antitumor Activity of Pt(II) Complexes Containing Diaminocarboxylates and Their Ester Derivatives
• Platinum Complexes of Diaminocarboxylates and Their Ethyl Ester Derivatives : Antitumor Activity and Interaction with Deoxyribonucleic Acid
• Cytotoxicity of Asymmetric Platinum Complexes against L-1210 Cells. Effect of Bulky Substituents
• オランダからの留学生(薬系大学における国際交流 : 海外からの留学生受け入れ)
• 高速液体クロマトグラフィ-による抗がん活性白金錯体とDNAおよび核酸塩基との相互作用に関する研究 (最新の化学分離法) -- (クロマトグラフィ-)
• STERIC EFFECT IN BINDING OF ANTITUMOR ACTIVE PLATINUM (II) COMPLEX TO NUCLEIC ACID BASE
• 制癌性白金錯体の研究
• Direct Determination of cis-Dichlorodiammineplatinum (II) in Urine by Derivative Spectroscopy
• 第9回毒物コントロールセンター欧洲連合国際会議, 国際裁判化学毒物者欧洲会議および第8回国際微量化学シンポジウム
• Studies on the Metal Chelate Compounds of Phenazine Derivatives. XI. Metal Chelates of 1-Phenazinethiol
• Studies on the Metal Chelate Compounds of Phenazine Derivatives. IX. : Formation Constants of Metal Chelates of Hydroxybenzo [a]-phenazine Derivatives
• Studies on the Mixed-Ligand Complexes. III. Mixed-Ligand Complexes between Alloxan and Glycine with Bivalent Metals
• Studies on the Mixed-Ligand Complexes. II. Synthesis of the Mixed-Ligand Complexes between 8-Hydroxyquinoline-5-sulfonic Acid and L-Histidine with Metals
• Studies on the Mixed Ligand Complexes. I. Synthesis of Glycine Oxine Cobalt (III) Complex
• Synthesis of 1-(Methylthio) phenazine Platinum (II) and Its S-demethylated Complexes
• 金属錯体化学からみた発癌と制癌
• Studies on the Metal Chelate Compounds of Phenazine Derivatives. XII. Far-infrared Spectra of the Metal Chelates of Hydroxyphenazine Derivatives
• 制がん作用をもった白金錯体 (金属イオンの生物活性--生物無機化学の新しい流れ)
• Preparation of Platinum (II) Complexes of Diamine Isomers [PtX (1,3-Diamine)] (X=Cl_2,SO_4,(NO_3)_2,Oxalato, D-Glucuronato, and D-Gluconato) and Determination of Their Antitumor Activity against Leukemia L1210
• Antitumor Activity of Platinum(2) Complexes of 1,2-Diamino-Cyclohexane Isomers
• Synthesis of Platinum (II) Complexes of 4-Substituted o-Phenylenediamine Derivatives and Determination of Their Antitumor Activity
• 白金錯体の合成と抗腫瘍活性
• 制がん作用を有する白金錯体

もっと見る 閉じる

スポンサーリンク