Direct Determination of cis-Dichlorodiammineplatinum (II) in Urine by Derivative Spectroscopy
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概要
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A derivative spectrophotometric method for the determination of the antitumor agent cis-dichlorodiammineplatinum (II) in urine has been developed. The method is based on the complexation of cis-dichlorodiammineplatinum (II) with N, N'-bis (3-mercapto-2-quinoxalinyl)-1,3-propanediamine. Optimum conditions for quantification of cis-dichlorodiammineplatinum (II) were established. The complex formed was stable in urine, and the recovery of platinum from urine was 92-95%. Interference arising from urine can be avoided by measurement of the second-order derivative spectrum. The relative standard deviations of the present method were 3.9% and 1.9% for the determination of 0.2 and 2.0 ppm of platinum in urine, respectively.
- 公益社団法人日本薬学会の論文
- 1985-08-25
著者
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喜谷 喜徳
Faculty of Pharmaceutical Sciences Nagoya City University
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稲垣 健治
Faculty of Pharmaceutical Sciences Nagoya City University
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喜谷 喜徳
名古屋市立大学薬学部
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米原 純子
Faculty of Pharmaceutical Sciences, Nagoya City University
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米原 純子
Faculty Of Pharmaceutical Sciences Nagoya City University
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