Synthesis and Antitumor Activity of Fused Quinoline Derivatives. III. Novel N-Glycosylamino-indolo[3,2-b]quinolines
スポンサーリンク
概要
- 論文の詳細を見る
Novel indolo[3,2-b]quinolines (1b-k), having a nitro, amino, acetamido, methanesulfonamido, or glycosylamino group at the 2,7,or 8-position, were prepared and their antitumor activities against P388 leukemia in mice were examined. The 7-galactopyranosylamino derivative (1g) showed the most potent activity (optimal dose=25mg/kg, T/C>333%, cure rate 5/6).
- 社団法人日本薬学会の論文
- 1992-06-25
著者
-
竹内 靖雄
岡山大学薬学部
-
竹内 靖雄
Faculty of Pharmaceutical Sciences, Okayama University
-
橋垣 国子
Faculty of Pharmaceutical Sciences, Okayama University
-
大和 正利
Faculty of Science, Okayama University of Science
-
張 明栄
Faculty of Pharmaceutical Science, Okayama University
-
田代 田鶴子
Cancer Chemotherapy Center
-
鶴尾 隆
Cancer Chemotherapy Center
-
塚越 茂
Cancer Chemotherapy Center
-
塚越 茂
癌研究会癌化学療法センター
-
塚越 茂
癌研究会癌研究所
-
田代 田鶴子
Division of Experimental Chemotherapy Cancer Chemotherapy Center
-
鶴尾 隆
財団法人癌研究会 癌化学療法センター
-
大和 正利
Faculty Of Pharmaceutical Sciences Okayama University
-
大和 正利
Faculty Of Science Okayama University Of Science
-
竹内 靖夫
Faculty Of Pharmaceutical Sciences Okayama University:cancer Chemotherapy Center
-
塚越 茂
帝国臓器製薬
-
張 明栄
Faculty Of Pharmaceutical Sciences Okayama University
-
橋垣 国子
Faculty Of Pharmaceutical Sciences Okayama University
-
橋垣 國子
Faculty Of Pharmaceutical Sciences Okayama University
関連論文
- ファーマコゲノミクス(PGx)の普及における課題
- 新モルヒネ経皮吸収型製剤とその臨床応用への可能性
- 182 ヒト非小細胞性肺癌株におけるカンプトテシン誘導体CPT-11の至適投与スケジュールの検討
- オクテット
- 抗マラリア化合物, Febrifugine の構造と合成
- Alkoxycarbonylmethylation of(3R, 10bS)-3-Phenyl-2,3,5,6-tetrahydro-10bH-oxazolo[2,3-a]isoquinoline
- Synthesis and Antitumor Activity of Fused Quinoline Derivatives. III. Novel N-Glycosylamino-indolo[3,2-b]quinolines
- Synthesis and Antitumor Activity of Fused Quinoline Derivatives. II. Novel 4- and 7-Hydroxyindolo-[3,2-b]quinolines
- Asymmetric syntheses of 1-Alkyltetrahydro-β-carbolines and a 9-Thio Analogue
- SYNTHESIS AND ANTITUMOR ACTIVITY OF 7-(N-GLYCOSYLAMINO)-INDOLO[3,2-b]QUINOLINES
- Asymmetric Synthesis of 1-Benzyltetrahydroisoquinolines Using Chiral Oxazolo[2,3-α]tetrahydro-isoquinolines
- Synthesis and Antitumor Activity of Fused Quinoline Derivatives
- The Wittig Reaction of Benzofuran-2,3-diones
- Syntheses and Antifungal Activities of dl-Griseofulvin and Its Congeners. I
- A Practical Synthetic Method for β-Ketoesters from Ketones
- One-Flask Synthesis of Sulfides from Alcohols and Alkyl Halides Using Benzoxazoline-2-thione
- A New Method for the Preparation of 2-(Alkylamino) benzoxazoles and 2-(Alkylimino) benzoxazolines
- A New Method for the Preparation of 2-Alkoxybenzoxazoles
- Synthesis of 3-Substituted Benzoxazoline-2-thiones
- Reaction of Benzoxazoline-2-thiones with Alkyl Halides
- Reaction of Anthranilamides with Levulinic Acids. Synthesis of 2,3,3a, 4-Tetrahydropyrrolo [2,1-b] quinazoline-1,9-diones
- Reaction of 1,2,3,4-Tetrahydroquinazolin-4-ones with Acid Anhydride. IV
- Reaction of 1,2,3,4-Tetrahydroquinazolin-4-ones with Acid Anhydride. III
- Reaction of 1,2,3,4-Tetrahydroquinazolin-4-ones with Acid Anhydride. II
- 癌化学療法 : 基礎から臨床へ
- 公開講座:シンボジウム-特殊病態下での抗菌薬・抗癌薬化学療法の問題点
- 癌化学療法-その問題点と将来
- 在宅治療を考慮した抗癌剤の開発 (癌の在宅治療)
- 抗癌剤の作用点と分類
- 新しい抗癌剤の開発動向
- バイオテクノロジ-素材としての培養細胞-13-癌化学療法
- THE SYNTHESIS AND ANTITUMOR ACTIVITIES OF TROPOLONE AND 8-HYDROXYQUINOLINE DERIVATIVES
- がん治療の本
- 癌治療の現場から(がん治療薬研究の現場から)
- Biological response modifier〔和文〕
- がん制圧の夢を語る
- 抗癌剤の研究
- Antineoplastic Activity of Platinum Complexes of trans-(dl)-1,2-Cyclopentanediamine
- Polycyclic N-Hetero Compounds. VI. Synthesis of 11,13,15-Triazasteroidal Compounds and Correction of the Structures of Its Intermediates
- Syntheses of 3-Substituted 1-Methyl-6-phenylpyrimido[5,4-e]-1,2,4-triazine-5,7(1H, 6H)-diones (6-Phenyl Analogs of Toxoflavin) and Their 4-Oxides, and Evaluation of Antimicrobial Activity of Toxoflavins and Their Analogs
- Condensation of Diethyl Acetonedicarboxylate. II
- Condensation of Diethyl Acetonedicarboxylate. I
- Chemical Structure and Sweet Taste of Isocoumarin and Related Compounds. VI
- Purification and Characterization of Mouse α_1-Acid Glycoprotein and Its Possible Role in the Antitumor Activity of Some Lichin Polysaccharides
- Syntheses and Antitumor Activities of 1R,2R-Cyclohexanediamine Pt(II) Complexes Containing Dicarboxylates(Medicinal Chemistry,Chemical)
- Polycyclic N-Hetero Compounds. XVI. Reactions of Benzyl Ketones with Formamide or Acetamide
- シンポジウム-バイオインフォーマティクスの薬学研究・薬学教育への応用と展開-(誌上シンポジウム)
- P-糖蛋白質の機能研究から耐性克服の分子標的治療への展開
- 腎細胞癌におけるmultidrug-resistance gene (MDRI)の発現と制癌剤自然耐性について
- 日本癌学会
- 細胞膜に注目した実験癌化学療法 : 制癌剤の効果増強と耐性の克服
- Cyanine Dyes, New Potent Antitumor Agents
- 抗腫瘍性トロポロン誘導体処理によるマウス乳癌細胞FM3Aにおけるデオキシヌクオシド三リン酸の不均衡とDNA二重鎖開裂(発表論文抄録(1991年))
- Polycyclic N-Hetero Compounds. VIII. Reactions of Ketones with Trisformylaminomethane
- Polycyclic N-Hetero Compounds. VII. Reactions of Benzyl Ketones with Formamide XI
- Photochemical Reaction of Isocoumarin and Related Compounds
- Polycyclic N-Hetero Compounds. XVII. Reactions of Heterocyclic Active Methyl Group with Formamide or Trisformylaminomethane
- Polycyclic N-Hetero Compounds. XV. The Vilsmeier Reaction of Phenylacetonitriles. II
- Synthesis and Structure-Activity Relationship of Spiro [isochroman-piperidine] Analogs for Inhibition of Histamine Release. IV.
- Synthesis and Structure-Activity Relationship of Spiro [isochroman-piperidine] Analogs for Inhibition of Histamine Release. III
- Synthesis and Antitumor Activity of Novel Dolastatin 10 Analogs
- オクテット
- Chemical Structure and Sweet Taste of Isocoumarin and Related Compounds. IX
- Chemical Structure and Sweet Taste of Isocoumarin and Related Compounds. VII
- Chemical Structure and Sweet Taste of Isocoumarins and Related Compounds
- Chemical Structure and Sweet Taste of Isocoumarins and Related Compounds. X. Syntheses of Sweet 5-Hydroxyflavanones and Related Dihydrochalcones
- Polycyclic N-Hetero Compounds. XIV. Reactions of Methylpyridines with Formamide
- Chemical Structure and Sweet Taste of Isocoumarins and Related Compounds Synthesis of 5-Hydroxyflavanones and Related Dihydrochalcones
- Polycyclic N-Hetero Compounds. XIII. Reactions of Pyridine N-Oxides with Formamide
- Chemical Structure and Sweet Taste of Isocoumarin and Related Compounds. VIII
- Polycyclic N-Hetero Compounds. XII. Reactions of Dihydroxynaphthalenes with Formamide or Trisformylaminomethane
- Polycyclic N-Hetero Compounds. XI. The Modified Vilsmeier Reaction of 4-Alkylpyrimidines
- Polycyclic N-Hetero Compounds. X. Reactions of 1,3-Cyclohexanedione and Its Dimer with Formamide or Trisformylaminomethane
- Polycyclic N-Hetero Compounds. IX. Reactions of Tetralones with Formamide or Trisformylaminomethane
- Synthesis and Structure-Activity Relationship of Spiro [isochroman-piperidine] Analogs for Inhibition of Histamine Release. II
- Synthesis and Antiulcer Activity of (Isochroman-1-yl)alkylamines. II
- Synthesis and Antiulcer Activity of (Isochroman-1-yl)alkylamines. I
- ANTITUMOR ACTIVITY OF ISOCHROMANYLTROPOLONES
- Synthesis and Biological Activity of Spiro [isocoumarin-piperidines] and Reltaed Compounds. I
- 内科100年の変遷 癌研究100年の変遷
- DDS研究と癌治療薬研究の将来展望
- 癌治療とDDS
- 癌化学療法のoverview - DDS研究の立場から -
- Platinum and Palladium Complexes Containing Ethylenediamine Derivatives as Carrier Ligands and Their Antitumor Activity
- Synthesis and Antitumor Activity of Pt (II) Complexes containing 2,3-Diaminopropanol Isomers
- Polycyclic N-Hetero Compounds. V. A Novel Synthesis of Isoquinoline by the Vilsmeier Reaction of Phenylacetonitriles
- Polycyclic N-Hetero Compounds. III. Synthesis of 1,3,10-Triazaphenanthrenes
- Synthesis of Pt(II) Complexes Containing D-Glucuronate, D-Gluconate, or Their Acetyl Derivatives and Evaluation of Antitumor Activity against Murine Leukemia L1210
- Synthesis and Antitumor Activity of Riboflavin and Flavin Mononucleotide Pt(II) Complexes
- Antitumor Activity of Pt(II) Complexes Containing Diaminocarboxylates and Their Ester Derivatives
- Platinum Complexes of Diaminocarboxylates and Their Ethyl Ester Derivatives : Antitumor Activity and Interaction with Deoxyribonucleic Acid
- 新規抗癌剤TZT-1027の抗腫瘍活性
- Reactivity of Isocoumarins. IV. Reaction of 1-Ethoxyisochroman with Nucleophilic Reagents
- Preparation of Platinum (II) Complexes of Diamine Isomers [PtX (1,3-Diamine)] (X=Cl_2,SO_4,(NO_3)_2,Oxalato, D-Glucuronato, and D-Gluconato) and Determination of Their Antitumor Activity against Leukemia L1210
- Antitumor Activity of Platinum(2) Complexes of 1,2-Diamino-Cyclohexane Isomers
- 天然物に創薬の手本を求めて
- 東京・渋谷名所の新薬学会館に(新薬学会館に望む)
- 日本薬学会教育賞受賞 田中善正氏
- Synthesis of a Griseofulvin Analogue
- Reaction of Spiro[piperidine-4,2'-(1', 2', 3', 4'-tetrahydroquinazolin)]-4'-ones with Acid Anhydrides