Synthesis and Structure-Activity Relationship of Spiro [isochroman-piperidine] Analogs for Inhibition of Histamine Release. II

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概要

• 論文の詳細を見る

• Structural modification of the isocoumarin moiety (A and B rings) of 1'-benzylspiro-[isocoumarin-piperidines] (1a and 2a), which inhibit the compound 48/80-induced release of histamine from isolated rat peritoneal mast cells, was undertaken to clarify the structure-activity relationship. Chromanone (3), chroman (4), 1,3-benzoxazine (5), 1,3-benzothiazine (6), and 4-quinazolinone (7) analogs were active, although there were differences in potency. Substituent effects on the benzene moiety (A ring) of 3 were examined.

• 公益社団法人日本薬学会の論文
• 1981-12-25

著者

• 橋垣 国子

  Faculty of Pharmaceutical Sciences, Okayama University

• 大和 正利

  Faculty of Science, Okayama University of Science

• 田坂 賢二

  Faculty of Pharmaceutical Sciences, Okayama University

• 田坂 賢二

  Faculty Of Pharmaceutical Sciences Okayama University

• 大和 正利

  Faculty Of Pharmaceutical Sciences Okayama University

• 津々 美明

  Faculty Of Pharmaceutical Sciences Okayama University

• 橋垣 国子

  Faculty Of Pharmaceutical Sciences Okayama University

• 橋垣 國子

  Faculty Of Pharmaceutical Sciences Okayama University

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