Effect of Compound 48/80 on the Phase Transition Temperature and Permeability of Liposomal Membrane
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概要
- 論文の詳細を見る
The action of compound 48/80 on liposomes prepared with dipalmitoylphosphatidylcholine (DPPC) and dicetylphosphate (DCP) was studied by means of fluorescence polarization and K^+ permeability measurements. Compound 48/80 interacted preferentially with DCP to decrease the phase transition temperature (T_c) of the membrane lipids. The K^+ release induced by 48/80 was temperature-dependent. It is proposed that the interaction between 48/80 and DCP forms a fluidlike domain in a rigid membrane matrix, resulting in the K^+ release from the liposomes.
- 公益社団法人日本薬学会の論文
- 1984-03-25
著者
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勝 孝
岡山大学薬学部
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勝 孝
岡山大薬
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田坂 賢二
Faculty of Pharmaceutical Sciences, Okayama University
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藤田 勇三郎
Faculty of Pharmaceutical Sciences, Okayama University
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勝 孝
Faculty Of Pharmaceutical Sciences Okayama University
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田坂 賢二
Faculty Of Pharmaceutical Sciences Okayama University
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藤田 勇三郎
Faculty Of Pharmaceutical Sciences Okayama University
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