Synthesis and Biological Activity of Spiro [isocoumarin-piperidines] and Reltaed Compounds. I

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概要

• 論文の詳細を見る

• 1'-Alkylspiro [isochroman-3,4'-piperidin]-1-ones (2) and 1'-alkylspiro [isochroman-4,4'-piperidines] (4 and 5) were prepared and examined for analgesic activity. Several of the 4-spiro compounds (3,4,and 5) were found to have analgesic activity as potent as that of aminopyrine, while the 3-spiro compounds (2) were inactive. Further pharmacological studies revealed that several of these compounds inhibited the histamine release induced by compound 48/80 from isolated rat peritoneal mast cells.

• 公益社団法人日本薬学会の論文
• 1981-02-25

著者

• 橋垣 国子

  Faculty of Pharmaceutical Sciences, Okayama University

• 大和 正利

  Faculty of Science, Okayama University of Science

• 田坂 賢二

  Faculty of Pharmaceutical Sciences, Okayama University

• 田坂 賢二

  Faculty Of Pharmaceutical Sciences Okayama University

• 大和 正利

  Faculty Of Pharmaceutical Sciences Okayama University

• 池田 雅夫

  Faculty Of Pharmaceutical Sciences Okayama University

• 橋垣 国子

  Faculty Of Pharmaceutical Sciences Okayama University

• 大竹 英俊

  Faculty of Pharmaceutical Sciences, Okayama University

• 橋垣 國子

  Faculty Of Pharmaceutical Sciences Okayama University

• 大竹 英俊

  Faculty Of Pharmaceutical Sciences Okayama University

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