ANTITUMOR ACTIVITY OF ISOCHROMANYLTROPOLONES
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概要
- 論文の詳細を見る
The reaction of 1-ethoxyisochroman (1) with 4-isopropyltropolone (2) (hinokitiol, β-thujaplicin) afforded 3-(1-isochromanyl)-6-isopropyltropo-lone (3). Compound 3 exhibited a potent inhibitory property against KB cell multiplication in vitro and antitumor activity against mouse leukemia P388 in vivo. On the other hand, 2 did not exhibit the antitumor activity in the in vivo system. In analogy with 1,the reaction of benzaldehyde diethyl acetal with 2 afforded 3-(α-ethoxybenzyl)-6-isopropyltropolone (7) and α, α-bis (6-iso-propyltropolon-3-yl) toluene (8). Compound 8 exhibited very potent antitumor activity.
- 公益社団法人日本薬学会の論文
- 1983-08-25
著者
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橋垣 国子
Faculty of Pharmaceutical Sciences, Okayama University
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石川 忠興
Faculty of Pharmaceutical Sciences, Okayama University
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橋垣 国子
Faculty Of Pharmaceutical Sciences Okayama University
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石川 維孝
Faculty of Pharmaceutical Sciences, Okayama University
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橋垣 國子
Faculty Of Pharmaceutical Sciences Okayama University
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石川 維孝
Faculty Of Pharmaceutical Sciences Okayama University
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石川 忠興
Faculty Of Pharmaceutical Sciences Okayama University
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