SYNTHESIS AND ANTITUMOR ACTIVITY OF 7-(N-GLYCOSYLAMINO)-INDOLO[3,2-b]QUINOLINES

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概要

• 論文の詳細を見る

• Novel indolo[3,2-b]quinolines (1d-g), introduced at the 7-position with an N-glycosylamino group, were prepared and thier antitumor activities against leukemia P388 in mice were examined. The N-Galactopyranosylamino derivative (1e) was a much more potent anti-leukemia compound (optimal dose = 25 mg/kg, T/C>333%, cure 5/6) than lead compound 1a.

• 社団法人日本薬学会の論文
• 1991-06-25

著者

• 竹内 靖雄

  岡山大学薬学部

• 竹内 靖雄

  Faculty of Pharmaceutical Sciences, Okayama University

• 橋垣 国子

  Faculty of Pharmaceutical Sciences, Okayama University

• 大和 正利

  Faculty of Science, Okayama University of Science

• 張 明栄

  Faculty of Pharmaceutical Science, Okayama University

• 大和 正利

  Faculty Of Pharmaceutical Sciences Okayama University

• 大和 正利

  Faculty Of Science Okayama University Of Science

• 竹内 靖夫

  Faculty Of Pharmaceutical Sciences Okayama University:cancer Chemotherapy Center

• 張 明栄

  Faculty Of Pharmaceutical Sciences Okayama University

• 橋垣 国子

  Faculty Of Pharmaceutical Sciences Okayama University

• 橋垣 國子

  Faculty Of Pharmaceutical Sciences Okayama University

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