Polycyclic N-Hetero Compounds. XV. The Vilsmeier Reaction of Phenylacetonitriles. II

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概要

• 論文の詳細を見る

• The Vilsmeier reaction of phenylacetonitriles to obtain intermediates of isoquinoline cyclization was described (refer to Chart 1). Phenylacetonitrile (I) gave β-dimethylamino-α-phenylacrylonitrile (II), α-formyl-(III) and α, N-diformyl- (IV) α-phenylacetamide, and 5,7-dioxo-2,6-diphenyl-4-aza-2-heptenamide (VI). m-Methoxyphenylacetonitrile (VII) gave α-(m-methoxyphenyl)-β-dimethylaminoacrylonitrile (VIII) and 3,5-bis (m-methoxyphenyl)-6-(N, N-dimethylaminomethyleneamino)-2(1H)-pyridone (IX). p-Methoxyphenylacetonitrile (XI) gave 2-[α-(β-carbamoyl)-p-methoxystyryl) amino]-6-chloro-3,5-bis(p-methoxyphenyl) pyridine (XII). 3,5-Dimethoxyphenylacetonitrile (XIV) gave 3-chloro-6,8-dimethoxyisoquinoline (XV) and 3-chloro-5-hydroxymethyl-6,8-dimethoxyisoquinoline (XVI). Phenylacetamides (V, X, XIII, XVII) were also obtained from respective nitriles (I, VII, XI, XIV).

• 公益社団法人日本薬学会の論文
• 1977-11-25

著者

• 大和 正利

  Faculty of Science, Okayama University of Science

• 小山 鷹二

  Faculty of Pharmaceutical Sciences, Medical School, Okayama University

• 廣田 喬

  Faculty Of Pharmaceutical Sciences Okayama University

• 大和 正利

  Faculty Of Pharmaceutical Sciences Okayama University

• 難波 哲人

  Faculty of Pharmaceutical Sciences, Okayama University

• 難波 哲人

  Faculty Of Pharmaceutical Sciences Okayama University

• 広田 喬

  岡山大学 薬

• 小山 鷹二

  Faculty Of Pharmaceutical Sciences Okayama University

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