天然物に創薬の手本を求めて
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概要
- 論文の詳細を見る
In reviewing my lifework, I wish to summarize the results of studies on the development of new biological-active compounds. The following subjects are discussed : 1) syntheses and biological activities of benzoxazole derivatives, 2) structure-activity relationships of phyllodulcin, a natural sweetner, and 3,4-dihydroisocoumarins for sweetness, 3) syntheses and structure-activity relationships of spiro [isocoumarin-piperidine] analogs for antiallergic activity, 4) design, structure-activity relationships, and a mechanism of antitumor action of bistropolone derivatives, 5) design, structure-activity relationships of fused tetracyclic quinolines for antitumor activity.
- 公益社団法人日本薬学会の論文
- 1992-02-25
著者
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大和 正利
Faculty of Science, Okayama University of Science
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大和 正利
Faculty Of Science Okayama University Of Science
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大和 正利
岡山大学薬学部
関連論文
- Alkoxycarbonylmethylation of(3R, 10bS)-3-Phenyl-2,3,5,6-tetrahydro-10bH-oxazolo[2,3-a]isoquinoline
- Synthesis and Antitumor Activity of Fused Quinoline Derivatives. III. Novel N-Glycosylamino-indolo[3,2-b]quinolines
- Synthesis and Antitumor Activity of Fused Quinoline Derivatives. II. Novel 4- and 7-Hydroxyindolo-[3,2-b]quinolines
- Asymmetric syntheses of 1-Alkyltetrahydro-β-carbolines and a 9-Thio Analogue
- SYNTHESIS AND ANTITUMOR ACTIVITY OF 7-(N-GLYCOSYLAMINO)-INDOLO[3,2-b]QUINOLINES
- Asymmetric Synthesis of 1-Benzyltetrahydroisoquinolines Using Chiral Oxazolo[2,3-α]tetrahydro-isoquinolines
- Synthesis and Antitumor Activity of Fused Quinoline Derivatives
- The Wittig Reaction of Benzofuran-2,3-diones
- Syntheses and Antifungal Activities of dl-Griseofulvin and Its Congeners. I
- A Practical Synthetic Method for β-Ketoesters from Ketones
- One-Flask Synthesis of Sulfides from Alcohols and Alkyl Halides Using Benzoxazoline-2-thione
- A New Method for the Preparation of 2-Alkoxybenzoxazoles
- Synthesis of 3-Substituted Benzoxazoline-2-thiones
- Reaction of Benzoxazoline-2-thiones with Alkyl Halides
- Reaction of Anthranilamides with Levulinic Acids. Synthesis of 2,3,3a, 4-Tetrahydropyrrolo [2,1-b] quinazoline-1,9-diones
- Reaction of 1,2,3,4-Tetrahydroquinazolin-4-ones with Acid Anhydride. IV
- Reaction of 1,2,3,4-Tetrahydroquinazolin-4-ones with Acid Anhydride. III
- Reaction of 1,2,3,4-Tetrahydroquinazolin-4-ones with Acid Anhydride. II
- THE SYNTHESIS AND ANTITUMOR ACTIVITIES OF TROPOLONE AND 8-HYDROXYQUINOLINE DERIVATIVES
- Polycyclic N-Hetero Compounds. VI. Synthesis of 11,13,15-Triazasteroidal Compounds and Correction of the Structures of Its Intermediates
- Syntheses of 3-Substituted 1-Methyl-6-phenylpyrimido[5,4-e]-1,2,4-triazine-5,7(1H, 6H)-diones (6-Phenyl Analogs of Toxoflavin) and Their 4-Oxides, and Evaluation of Antimicrobial Activity of Toxoflavins and Their Analogs
- アルド-ルおよび関連反応におけるChiralなアルデヒドのジアステレオ面選択性
- Condensation of Diethyl Acetonedicarboxylate. II
- Condensation of Diethyl Acetonedicarboxylate. I
- Chemical Structure and Sweet Taste of Isocoumarin and Related Compounds. VI
- Polycyclic N-Hetero Compounds. XVI. Reactions of Benzyl Ketones with Formamide or Acetamide
- 抗腫瘍性トロポロン誘導体処理によるマウス乳癌細胞FM3Aにおけるデオキシヌクオシド三リン酸の不均衡とDNA二重鎖開裂(発表論文抄録(1991年))
- Polycyclic N-Hetero Compounds. VIII. Reactions of Ketones with Trisformylaminomethane
- Polycyclic N-Hetero Compounds. VII. Reactions of Benzyl Ketones with Formamide XI
- Photochemical Reaction of Isocoumarin and Related Compounds
- Polycyclic N-Hetero Compounds. XVII. Reactions of Heterocyclic Active Methyl Group with Formamide or Trisformylaminomethane
- Polycyclic N-Hetero Compounds. XV. The Vilsmeier Reaction of Phenylacetonitriles. II
- Synthesis and Structure-Activity Relationship of Spiro [isochroman-piperidine] Analogs for Inhibition of Histamine Release. IV.
- Synthesis and Structure-Activity Relationship of Spiro [isochroman-piperidine] Analogs for Inhibition of Histamine Release. III
- Diphenylethane系化合物の立体構造
- Chemical Structure and Sweet Taste of Isocoumarin and Related Compounds. IX
- Chemical Structure and Sweet Taste of Isocoumarin and Related Compounds. VII
- Chemical Structure and Sweet Taste of Isocoumarins and Related Compounds
- Chemical Structure and Sweet Taste of Isocoumarins and Related Compounds. X. Syntheses of Sweet 5-Hydroxyflavanones and Related Dihydrochalcones
- Polycyclic N-Hetero Compounds. XIV. Reactions of Methylpyridines with Formamide
- Chemical Structure and Sweet Taste of Isocoumarins and Related Compounds Synthesis of 5-Hydroxyflavanones and Related Dihydrochalcones
- Polycyclic N-Hetero Compounds. XIII. Reactions of Pyridine N-Oxides with Formamide
- Chemical Structure and Sweet Taste of Isocoumarin and Related Compounds. VIII
- Polycyclic N-Hetero Compounds. XII. Reactions of Dihydroxynaphthalenes with Formamide or Trisformylaminomethane
- Polycyclic N-Hetero Compounds. XI. The Modified Vilsmeier Reaction of 4-Alkylpyrimidines
- Polycyclic N-Hetero Compounds. X. Reactions of 1,3-Cyclohexanedione and Its Dimer with Formamide or Trisformylaminomethane
- Polycyclic N-Hetero Compounds. IX. Reactions of Tetralones with Formamide or Trisformylaminomethane
- Synthesis and Structure-Activity Relationship of Spiro [isochroman-piperidine] Analogs for Inhibition of Histamine Release. II
- Synthesis and Antiulcer Activity of (Isochroman-1-yl)alkylamines. II
- Synthesis and Antiulcer Activity of (Isochroman-1-yl)alkylamines. I
- Synthesis and Biological Activity of Spiro [isocoumarin-piperidines] and Reltaed Compounds. I
- 3,4-Dihydroisocoumarin類のAminolysis
- Polycyclic N-Hetero Compounds. V. A Novel Synthesis of Isoquinoline by the Vilsmeier Reaction of Phenylacetonitriles
- Polycyclic N-Hetero Compounds. III. Synthesis of 1,3,10-Triazaphenanthrenes
- Reactivity of Isocoumarins. IV. Reaction of 1-Ethoxyisochroman with Nucleophilic Reagents
- 天然物に創薬の手本を求めて
- 東京・渋谷名所の新薬学会館に(新薬学会館に望む)
- 日本薬学会教育賞受賞 田中善正氏
- Synthesis of a Griseofulvin Analogue
- アルドールおよび関連反応におけるChiralなアルデヒドのジアステレオ面選択性