Syntheses and Biological Activities of N-Alkyl-and N-Alkenylcarbamoyl Phospholipids
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概要
- 論文の詳細を見る
Various carbamate analogs of lysophospholipids, N-alkyl-and alkenylcarbamoyl phospholipids (ACPLs), were synthesized and their antimicrobial properties were examined. The ACPLs studied differed in certain aspects of their chemical structure : the polar-head base, the aliphatic nonpolar tail attached to the carbamate nitrogen and the molecular backbone, e.g., 2-O-methylglycerol and 1,3-propanediol. In contrast to lysolecithin and lecithin, the majority of the ACPLs showed inhibitory activities against Tetrahymena pyriformis (protozoan) and a range of fungi. In the series of ACPLs studied, the maximal inhibitory activities were observed with 2-O-methyl-1-O-(N-tetradecyl) carbamoylglycero-3-phosphocholine (3-C_<14>-A) and its 2-demethoxy compound (4-C_<14>-A). In comparison with clotrimazole, these compounds showed more potent activities against T. pyriformis, and comparable or lower activities against human pathogenic and phytopathogenic fungi. The relationships between structure and antimicrobial activity are discussed.
- 社団法人日本薬学会の論文
- 1984-07-25
著者
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穂積 本男
Department Of Chemotherapy Saitama Cancer Center Research Institute
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穂積 本男
Department Of Chemotherapy Saitama Cancer Center Research Institure
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野村 容朗
Central Research Division, Takeda Chemical Ind., Ltd.,
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野島 庄七
Faculty of Pharmaceutical Sciences, University of Tokyo
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野村 容朗
Research and Development Division, Eisai Company, Ltd.,
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吉岡 義夫
Central Research Division, Takeda Chemical Industries, Ltd.
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吉岡 義夫
Central Research Division Takeda Chemical Ind. Ltd.
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津島 進
Central research Division, Takeda Chemical Ind., Ltd.
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谷田 清一
Central research Division, Takeda Chemical Ind., Ltd.
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津島 進
Central Research Division Takeda Chemical Industries Ltd.
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野島 庄七
Faculty Of Pharmaceutical Sciences University Of Tokyo
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野村 容朗
Research And Development Division Eisai Company Ltd.
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谷田 清一
Central Research Division Takeda Chemical Industries Ltd.
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Nomura Hiroaki
Research And Development Division Eisai Company Ltd.
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