A New Route to Semisynthetic Cephalosporins from Deacetylcephalosporin C. I. Synthesis of 3-Heterocyclicthiomethyl-cephalosporins
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概要
- 論文の詳細を見る
New compounds 3-acetoacetoxymethyl-7β-acylaminoceph-3-em-4-carboxylic acids (4) were synthesized from deacetylcephalosporin C (3a), after N-protection of the amino-adipoyl group followed by acetoacetylation of the 3'-hydroxyl with diketene and acyl exchange at the 7-position. They underwent a facile nucleophilic displacement of the 3'-acetoacetoxy group with heterocyclic thiols to afford 7β-acylamino-3-heterocyclicthio-methylceph-3-em-4-carboxylic acids (6) including SCE-963 (6e) in good yields.
- 社団法人日本薬学会の論文
- 1979-03-25
著者
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千代 道行
Central Research Division, Takeda Chemical Industries, Ltd.
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千代 道行
Central Research Division Takeda Chemical Industries Ltd.
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津島 進
Medicinal Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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千代 道行
Medicinal Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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白石 充
Medicinal Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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加藤 昌靖
Medicinal Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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松本 憲親
Medicinal Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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内藤 建三
Medicinal Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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沼田 光雄
Medicinal Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
-
加藤 昌靖
Medicinal Research Laboratories Central Research Division Takeda Chemical Industries Ltd.
-
津島 進
Central Research Division Takeda Chemical Industries Ltd.
-
沼田 光雄
Medicinal Research Laboratories Central Research Division Takeda Chemical Industries Ltd.
-
白石 充
Medicinal Research Laboratories Central Research Division Takeda Chemical Industries Ltd.
-
内藤 建三
Medicinal Research Laboratories Central Research Division Takeda Chemical Industries Ltd.
-
松本 憲親
Medicinal Research Laboratories Central Research Division Takeda Chemical Industries Ltd.
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