Synthesis of Aristeromycin Analogs
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概要
- 論文の詳細を見る
Reaction of aristeromycin (I) with acetyl bromide in acetonitrile, followed by treatment with hydrobromic acid afforded 3'β-bromo-3'-deoxyaristeromycin hydrobromide (V) and 2'β-bromo-2'-deoxyaristeromycin hydrobromide (VI). Catalytic reduction of V and VI with palladium on charcoal gave 3'-deoxyaristeromycin (X) and 2'-deoxyaristeromycin (XI), respectively. Treatment of V with sodium alkoxide yielded 2', 3'-anhydroaristeromycin (IV). Two carbocyclic analogs (XII and XV) of inosine and 6-mercaptopurine ribonucleoside, 8-bromoaristeromycin (XVI) and 8-hydroxyaristeromycin (XVII) were also prepared.
- 社団法人日本薬学会の論文
- 1976-11-25
著者
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丸本 龍二
Central Research Laboratories Takeda Chemical Industries Ltd.
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丸本 龍二
Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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吉岡 義夫
Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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古川 純康
Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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本庄 美喜男
Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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吉岡 義夫
Central Research Division Takeda Chemical Ind. Ltd.
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本庄 美喜男
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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古川 純康
Chemistry Laboratories Central Research Division Takeda Chemical Industries Ltd.
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