Fused Pyrimidines. II. Synthesis and Oxidation of 3-Aminoisothiazolo [3,4-d] pyrimidines
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概要
- 論文の詳細を見る
Reaction of 6-aminouracils (I) with alkyl or aryl isothiocyanates afforded 6-amino-5-substituted thiocarbamoyluracils (II), which were oxidized with bromine or hydrogen peroxide to afford 3-(substituted) aminoisothiazolo [3,4-d] pyrimidin-4,6-(5H, 7H)-diones (III). Alkylation of III afforded 3-(N, N-disubstituted) amino derivatives (V). Further oxidation of 1,3-diethyl-3-dimethylamino-or-3-methylaminoisothiazolo [3,4-d] pyrimidin-4,6-(5H, 7H)-dione (Vb or IIIb) with hydrogen peroxide afforded 1,3-diethyl-5-alkylcarbamoyl-5-hydroxybarbituric acid (Xa or Xb). Treatment of Xa with Raney nickel afforded 1,3-diethyl-5-dimethylcarbamoylbarbituric acid (XII).
- 公益社団法人日本薬学会の論文
- 1976-05-25
著者
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古川 純康
Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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古川 純康
Chemistry Laboratories Central Research Division Takeda Chemical Industries Ltd.
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島 俊介
Chemical Research Laboratories, Central Research Division Takeda Chemical Industries, Ltd.
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