Addition of 4-Ethoxyimidazoles to Dimethyl Acetylenedicarboxylate and Transformation of the Adducts to Pyrimidin-5-yl Acetates
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概要
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Four new 4-ethoxy-2-substituted imidazoles (1) were synthesized and high reactivity toward electrophiles was observed at the 5-position rather than the N atoms. For example, 1 reacted with dimethyl acetylenedicarboxylate to afford dimethyl (4-ethoxyimidazol-5-yl)fumarates (6) and-maleates (5). When 6 was treated with acid, a novel ring transformation occurred to give methyl (6-ethoxycarbonyl-3,4-dihydro-4-oxopyrimidin-5-yl)acetates (12).
- 公益社団法人日本薬学会の論文
- 1988-05-25
著者
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古川 純康
Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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大村 晴
Chemistry Laboratories Central Research Division Takeda Chemical Industries Ltd.
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古川 純康
Chemistry Laboratories Central Research Division Takeda Chemical Industries Ltd.
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古矢 修一
Chemistry Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.,
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古矢 修一
Chemistry Laboratories Central Research Division Takeda Chemical Industries Ltd.
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