Synthesis of Purine Derivatives from Single-carbon Compounds
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概要
- 論文の詳細を見る
The reaction of chloroform with liq. ammonia in a sealed vessel at high temperatures furnished adenine, purine, and 8-aminopurine in 5,7 and 1% yields, respectively. Similarly, the reaction between ethyl orthoformate and liq. ammonia yielded adenine (21%), purine (14%) and 8-aminopurine (3%), A possible mechanism has been proposed for the reaction, which involves a polymerization of formimidoyl derivative rather than an intermediary formation of aminomalononitrile.
- 公益社団法人日本薬学会の論文
- 1969-04-25
著者
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小林 邦夫
Diagnostic Science Department Shionogi & Co. Ltd.
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本庄 美喜男
Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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本庄 美喜男
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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小林 邦夫
Chemical Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd.
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