Synthesis and Physicochemical Properties of 6-O-Cyclopyrimidine Nucleosides
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概要
- 論文の詳細を見る
Cyclization of 5-iodo-1-(β-D-xylofuranosyl) uracil and -cytosine with sodium methoxide afforded 6,3'-O-cyclouridine (IIa) and -cytidine (IIc), respectively. The rate of cyclization of 5-iodopyrimidine nucleosides is greatly dependent on the ring size formed on cyclization. Introduction of a trityl group at the 5'-position of the nucleoside brought about a decrease in the rate of cyclization. The ease with which ring-opening of 6-O-cyclouracil nucleoside isomers was effected with diluted sulfuric acid was in the opposite order to that of cyclization. The ultraviolet, circular dichroism and mass spectra of 6-O-cyclopyrimidine nucleosides and their isomers were compared.
- 公益社団法人日本薬学会の論文
- 1982-08-25
著者
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丸山 徳見
School of Pharmacy, Tokushima Bunri University
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本庄 美喜男
School of Pharmacy, Tokushima Bunri University
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佐藤 澄子
School Of Pharmacy Tokushima Bunri University
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本庄 美喜男
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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丸山 徳見
徳島文理大 薬
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