Improved Procedures for the Syntheses of Pyrido- and Pyrrolo[2,3-d]pyrimidines, and Ribosides Thereof

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概要

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• Pyrido[2,3-d]pyrimidines were obtained by treatment of 6-allylaminouracils with PdCl_2 at 60 ℃, under which conditions the yields of the products were improved to a considerable extent as compared with our previously reported reaction. Pyrrolo[2,3-d]pyrimidines were prepared under the above conditions from 6-(N-allyl-N-methylamino)uracils which were substituted with a methyl group at 6-NH of uracil. In addition, pyrido- and pyrrolo[2,3-d]pyrimidine nucleosides were prepared from 6-(substituted allyl- or N-allyl-N-methylamino)uridines by adaptation of the above method. That is, the presence or absence of a substituent on the 6-amino group influences the size of ring formed. We proposed plausible pathways to explain why products having different ring sizes were formed.

• 社団法人日本薬学会の論文
• 1989-12-25

著者

• 水野 義久

  School Of Pharmaceutical Sciences Kitasato University

• 水野 義久

  北海道大学 薬

• 小倉 治夫

  School of Pharmaceutical Sciences, Kitasato University

• 小倉 治夫

  北里大学

• 小倉 治夫

  School Of Pharmaceutical Sciences Kitasato University

• 穂積 本男

  Department Of Chemotherapy Saitama Cancer Center Research Institute

• 穂積 本男

  Department Of Chemotherapy Saitama Cancer Center Research Institure

• 伊東 常男

  School of Pahrmaceutical Sciences, Kitasato University

• 石川 一郎

  School of Pahrmaceutical Sciences, Kitasato University

• 川原 徳夫

  Hokkaido Institute of Pharmaceutical Sciences

• 本間 良夫

  Department of Chemotherapy, Saitama Cancer Center Research Institure

• 伊東 常男

  School Of Pharmaceutical Sciences Kitasato University

• 川原 徳夫

  北海道薬大

• 石川 一郎

  School Of Pharmaceutical Sciences Kitasato University

• Melik-ohanjanian Raphael

  The Department Of Heterocyclic Chemistry Mnjoyan Institute Of Fine Organic Chemistry Academy Of Scie

• 本間 良夫

  Department Of Chemotherapy Saitama Cancer Center Research Institure

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