Photochemical Synthesis of Fused Tricyclic Compounds from Bis-6,6'-(1,3-dialkyluracilyl) sulfides

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概要

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• Bis-6,6'-(1,3-dialkyluracilyl) sulfides (3) were synthesized by coupling of 6-chloro-1,3-dialkyluracil (1) and 1,3-dialkyluracil-6-mercaptide (2). Compounds (3) were found to undergo photochemical cyclization, giving rise to three types of isolable products with novel ring systems, namely, 1,3,6,8-tetraalkyl [1,4] dithiino [2,3-d ; 5,6-d'] dipyrimidines (4), 1,3,6,8-tetraalkylthiopheno [2,3-d ; 4,5-d'] dipyrimidines (6) and the dihydro derivatives (8) of the latter. These compounds were fully characterized by 'H-NMR, mass spectral and elemental analyses. A plausible mechanism for this photocyclization of 3 to 6 and to 8 has been proposed.

• 社団法人日本薬学会の論文
• 1981-04-25

著者

• 小倉 治夫

  School of Pharmaceutical Sciences, Kitasato University

• 小倉 治夫

  School Of Pharmaceutical Sciences Kitasato University

• 伊東 常男

  School of Pahrmaceutical Sciences, Kitasato University

• 川原 徳夫

  Hokkaido Institute of Pharmaceutical Sciences

• 渡辺 恭一

  Sloan-kettering Instiute For Cancer Research Memorial Sloan-kettering Cancer Center:sloan-kettering

• 伊東 常男

  School Of Pharmaceutical Sciences Kitasato University

• 渡辺 恭一

  Institute for Cancer Research, Sloan-Kettering Division of Graduate School of Medicinal Sciences, Co

• 川原 徳夫

  U.S.A. and Hokkaido College of Pharmacy

• 川原 徳夫

  北海道薬大

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