A Novel One-Step Synthesis of Thioquinazoline Glycosides and Pyrazolopyrimidine Glycoside Analogs
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概要
- 論文の詳細を見る
The reaction of glycosyl isothiocyanates (1a, b, c) with anthranilic acid gave corresponding glycosyl thioquinazolines (3a, b, c) in the presence of zinc chloride in excellent yields. The reaction performed in the absence of zinc chloride afforded the intermediate glycosyl thioureides (2a, b) along with the cyclized compounds. However, similar treatment of 1a with 2-amino-3-carboethoxypyridine did not give the corresponding glycosyl pyridopyrimidine (5a), but glycosyl thioureide (4a) was obtained in good yield. Attempted ring closure of 4a under neutral or acidic conditions failed. Similar reactions of 1a, b, and c with 3-aminopyrazole-4-carboxylic acid in the presence of zinc chloride afforded corresponding pyrazolo [4,3-e] pyrimidine glycosides (6a, b and c) in fair yields.
- 社団法人日本薬学会の論文
- 1979-05-25
著者
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小倉 治夫
School of Pharmaceutical Sciences, Kitasato University
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高橋 洋
School Of Pharmaceutical Sciences Kitasato University
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小倉 治夫
School Of Pharmaceutical Sciences Kitasato University
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二村 典行
School of Pharmaceutical Sciences, Kitasato University
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二村 典行
School Of Pharmaceutical Sciences Kitasato University
関連論文
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