Studies on the Chlorinated α-Santonins. IV. : Chlorination of α-Santonin and Stereochemistry Therein
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概要
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Addition of chlorine to the double bond of α-santonin derivatives such as santonin chlorohydrin (4) santonin α-epoxide (5), and 5-chloro-4-methoxysatonin (6) produced new chloro-santonins (13,14,16,respectively). So far, only trans addition of chlorine to the 1,2-double bond of santonin has been known, but from the configuration of these products, it wa clear that cis addition had occuured. 'Santonin dichloride' (2), and 2-chlorosantonin (3), were chloromethoxylated and chloro-hydroxylated to produce tetrasubstituted compounds (9 and 10), and trisubstituted compounds (11 and 12), respectively. Their structure and configuration were determined by interrelating them to known santonin derivatives (2,3,4,5,and 6) and by X-ray analysis of 13.
- 公益社団法人日本薬学会の論文
- 1990-03-25
著者
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小倉 治夫
School of Pharmaceutical Sciences, Kitasato University
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高柳 弘明
School of Pharmaceutical Sciences, Kitasato University
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小倉 治夫
北里大学
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小倉 治夫
School Of Pharmaceutical Sciences Kitasato University
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高柳 弘明
北里大学薬学部薬化学教室
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高柳 弘明
School Of Pharmaceutical Sciences Kitasato University
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McMURRY T.Brain
University Chemical Laboratory, Trinity College
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Mcmurry T.brain
University Chemical Laboratory Trinity College
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