シアル酸をリード化合物とする生理活性物質の探索
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概要
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In this review, I wish to summarize studies on sialic acid-N-acetylneuraminic acid (Neu 5Ac), N-glycoloylneuraminic acid (Neu 5Gc), 3-deoxy-D-glycero-D-galacto-nonulopyranosonic acid (KDN), and their alkyl, acyl, dehydro and deoxy derivatives. Our working strategy is"cell component derivatives of sialic acid which have a good shape and good balance between hydrophilicity and hydrophobicity, would elicit various kinds of physiological activities."Preparation and physiological activities of sialic acid derivatives, and a new method of stereochemistry determination are reported. Several derivatives show remarkable physiological activities for novel medicines in the XXI century. A generic name'GLYCOLIPOID'is proposed for such compounds.
- 公益社団法人日本薬学会の論文
- 1994-05-25
著者
関連論文
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