ヌクレオシド類と塩化水銀および塩化カドミウムの錯形成能について

概要

論文の詳細を見る
Through the observation of chemical shifts in nuclear magnetic resonance spectra, formation constants of 1 : 1 metal complexes with nucleosides were found in dimethyl sulfoxide at room temperature. The complex formation constants of CdCl_2-adenine and CdCl_2-benzyladenine are 1.6-1.7 times larger than the values for the HgCl_2 complexes of adenine and benzyladenine. On the other hand, the formation constant of HgCl_2-6-mercaptopurine is larger than the value of CdCl_2-6-mercaptopurine. 6-Methylmercaptopurine did not complex with HgCl_2 or CdCl_2. In nucleosides, the complex formation constant with HgCl_2 is in the order of 4-thiouridine, cyclocytidine, and cytidine. The complex formation with HgCl_2 or CdCl_2 was not observed with nucleoside analogs prepared from 5,6-diamino-1,3-dimethyluracil with D-glucose or D-galactose.
公益社団法人日本薬学会の論文
1978-06-25