Studies on Heterocyclic Compounds. XII. A Novel Synthesis of 5-Oxo- and 7-Oxo-pyrido [2,3-d] pyrimidines
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概要
- 論文の詳細を見る
A simple synthesis of pyrido [2,3-d] pyrimidine derivatives as an antitumor agent was reported. Reaction of 6-amino- and 6-(substituted) amino-1,3-dimethyluracil (I) with dimethyl acetylenedicarboxylate in methanol afforded a mixture of 5-oxo- and 7-oxopyrido-[2,3-d] pyrimidines and an open-chain intermediate. This intermediate was proved to be 5-substituted 6-aminopyrimidine (VIa), and to be cyclized to 7-oxopyrido [2,3-d] pyrimidine (VIIIa). On the other hand, 5-oxo compounds were obtained from the reaction of I with diketene or ethyl acetoacetate.
- 公益社団法人日本薬学会の論文
- 1973-09-25
著者
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小倉 治夫
School Of Pharmaceutical Sciences Kitasato University
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坂口 正一
School Of Pharmaceutical Sciences Kitasato University
関連論文
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