Studies on Heterocyclic Compounds. XXXII. Synthesis of 8-Substituted Theophyllines from 6-Amino-5-benzylideneamino-1,3-dimethyluracils with Nickel Peroxide
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概要
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Oxidation of 6-amino-5-benzylideneamino-1,3-dimethyluracils (Ia-e) with nickel peroxide (Ni-PO) in dimethylsulfoxide (DMSO) afforded 8-substituted theophyllines (IIa-e) and dimethylsulfone. Ni-PO oxidation of the Schiff base acetate (V) of 5,6-diamino-1,3-dimethyluracil with D-glucose did not give a nucleoside analog ; in stead, 1,3,7,9-tetramethyl-2,4,6,8-(1H, 3H, 7H, 9H)pyrimido[5,4-g]pteridinetetrone (VI) and penta-O-acetylgluconic acid were obtained. The reaction mechanisms of Ni-PO and the Schiff bases (Ia-e, V) are discussed.
- 公益社団法人日本薬学会の論文
- 1980-09-25
著者
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小倉 治夫
School of Pharmaceutical Sciences, Kitasato University
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小倉 治夫
School Of Pharmaceutical Sciences Kitasato University
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峯尾 哲
School Of Pharmaceutical Sciences Kitasato University
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中川 国夫
School Of Pharmaceutical Sciences Kitasato University
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中川 国夫
Faculty of Pharmaceutical Sciences, Tokushima University of Arts and Science
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