Studies on Lactams. V. Nucleophilic Reaction of Benzylpenicillin with Lithiated Compounds
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概要
- 論文の詳細を見る
Nucleophilic reaction of penicillin lactam with various lithiated compounds was discussed. Phenacyl benzylpenicillanate was reacted with phenylethynyllithium in tetrahydrofuran at -75°to yield a phenylethynyl derivative (2). When methyllithium or phenyllithium was used as the reagent in ether at -75°, only a ring-opened compound (4) was obtained. On the other hand, use of butyllithium or phenyllithium in tetrahydrofuran at -75° afforded an unexpected butoxycarbonyl derivative (5). The butoxyl group was derived from tetrahydrofuran, and which was confirmed by the formation of butanol from the reaction of tetrahydrofuran and phenyllithium at -75°.
- 社団法人日本薬学会の論文
- 1975-11-25
著者
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小倉 治夫
School of Pharmaceutical Sciences, Kitasato University
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高橋 洋
School Of Pharmaceutical Sciences Kitasato University
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小倉 治夫
School Of Pharmaceutical Sciences Kitasato University
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武田 収功
School of Pharmaceutical Sciences, Kitasato University
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武田 収功
School Of Pharmaceutical Sciences Kitasato University
関連論文
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