Studies on Sialic Acids. IX. : Formation of a 1,7-Lactone Derivative by Direct Acetylation of N-Acetylneuraminic Acid

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概要

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• A new lactone compound was isolated as a minor by-product from the reaction mixture of N-acetylneuraminic acid with acetic anhydride in pyridine, in addition to the major product, 2,4,7,8,9-penta-O-acetyl-N-acetylneuraminic acid. The structure of the new compound was elucidated to be 5-acetamido-2,4,8,9-tetra-O-acetyl-3,5-dideoxy-β-D-glycero-D-galacto-2-nonulopyranosono-1,7-lactone by nuclear magnetic resonance, mass spectroscopy and X-ray crystal analysis. It was revealed that the absolute configurations of the asymmetric centers of the new compound were consistent with those for the original N-acetylneuraminic acid with the conversion of the pyranose ring conformation from ^2C_5(D) to ^5C_2(D).

• 公益社団法人日本薬学会の論文
• 1988-03-25

著者

• 古畑 公夫

  School of Pharmaceutical Sciences, Kitasato University

• 小倉 治夫

  School of Pharmaceutical Sciences, Kitasato University

• 高柳 弘明

  School of Pharmaceutical Sciences, Kitasato University

• 小倉 治夫

  School Of Pharmaceutical Sciences Kitasato University

• 菅井 啓

  メクト株式会社東京研究所

• 高柳 弘明

  北里大学薬学部薬化学教室

• 高柳 弘明

  School Of Pharmaceutical Sciences Kitasato University

• 後藤 元彰

  (株)埼玉第一製薬

• 菅井 啓

  Central Research Institute, MECT Corporation

• 杉山 直和

  Central Research Institute, MECT Corporation

• 杉山 直和

  メクト株式会社東京研究所

• 山田 宣之

  Central Research Institute, MECT Corporation

• 後藤 元彰

  Central Research Institute, MECT Corporation

• 伴 千恵子

  Central Research Institute, MECT Corporation

• 伴 千恵子

  Central Research Institute Mect Corporation

• 山田 宣之

  Central Research Institute Mect Corporation

関連論文

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