Studies on Nucleosides Analogs. XVIII. Synthesis of Pyrimido-[4,5-c] pyridazine Nucleoside Analogs
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概要
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The reactions of 6-hydrazino-1,3-dimethyluracil (1) with aldoses (2a-e), D-fructose, and D-glucuronolactone gave hydrazones (3a-e, 6,and 8) in good yields, and these products were converted to pyrimido [4,5-c] pyridazine nucleoside analogs (4a-e, 7,and 9) by cyclodehydration. Stereoisomers were isolated from the reaction mixtures of pyrimido [4,5-c] pyridazine derivatives, and were examined by CD spectroscopy. On the other hand, the hydrazones (11a, b) of 1 with glycolaldehyde or (±)-glyceraldehyde were converted only to acetates (12a, b). Formation of the pyrimido [4,5-c]-pyridazine derivatives (13a, b) was not observed.
- 1981-03-25
著者
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小倉 治夫
School Of Pharmaceutical Sciences Kitasato University
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坂口 正一
School Of Pharmaceutical Sciences Kitasato University
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竹内 尚子
School Of Pharmaceutical Sciences Kitasato University
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仲田 遣功
School Of Pharmaceutical Sciences Kitasato University
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樋田 伸子
School of Pharmaceutical Sciences, Kitasato University
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樋田 伸子
School Of Pharmaceutical Sciences Kitasato University
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