Studies on Sialic Acids. XI. : Synthesis of 2-O-Clycosyl Derivatives of N-Acetylneuraminic Acid
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概要
- 論文の詳細を見る
The reactions of methyl N-acetyl-4,7,8,9-tetra-O-acetyl-2-chloro-2-deoxy-β-D-neuraminate (2) with 2', 3'-di-O-acetylinosine (1) and with 2', 3'-di-O-acetyl-N-benzoylcytidine (8) under Koenigs-KOnorr-like reaction conditions geve the corresponding (2→5) linked disaccharide uncleoside analogues, in yields of 31% and 23% respectively. These nucleoside 5'-N-acetylneuraminic acid analogues were converted via saponification or ammonolysis into the final target compounds. The stereochemistry of these. compounds was confirmed by analysis. of the proton nuclear magnetic resonance (^1H-NMR) spectra and measurement of the rate of hydrolysis of the (2→5) glycosidic linkage.
- 社団法人日本薬学会の論文
- 1988-03-25
著者
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佐藤 慎吾
School Of Pharmaceutical Sciences Kitasato University
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古畑 公夫
School of Pharmaceutical Sciences, Kitasato University
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小倉 治夫
School of Pharmaceutical Sciences, Kitasato University
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伊藤 正善
Central Research Laboratory, MECT Co., Ltd.,
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志鳥 善保
Central Research Laboratory, MECT Co., Ltd.,
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小倉 治夫
School Of Pharmaceutical Sciences Kitasato University
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佐藤 慎吾
北里大学 薬
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伊藤 正善
メクト中研
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志鳥 善保
メクト中研
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