Nucleosides. CXLIV. Some Reactions of 2'-O-Triflyl-2,3'-anhydroxylosyluracil with Nucleophilic Reagents. Synthesis of 2'-Chloro-2',3'-dideoxyuridinene. Studies Directed toward the Synthesis of 2'-Deoxy-2'-substituted arabino Nucleosides.(5)(Organic,Chemic
スポンサーリンク
概要
- 論文の詳細を見る
Treatment of 2,3'-anhydro-1-(5-O-acetyl-2-O-triflyl-f-D-xylofuranosyl)uracil with LiCl in hexamethylphosphoric triamide afforded the 2'-"up" chloride of the anhydronucleoside, i.e., the 2'-triflate group was directly displaced by the chloride nucleophile. All attempts to hydrolyze the 2,3'-anhydro linkage resulted in the formation of 2'-chloro-2',3'-didehydro-dideoxynucleoside.
- 公益社団法人日本薬学会の論文
- 1987-11-25
著者
-
渡辺 恭一
Sloan-kettering Instiute For Cancer Research Memorial Sloan-kettering Cancer Center:sloan-kettering
-
PANKIEWICZ KRZYSZTOF
Sloan-Kettering Instiute for Cancer Research, Memorial Sloan-Kettering Cancer Center
-
Pankiewicz Krzysztof
Sloan-kettering Institute For Cancer Research Memorial Sloan-kettering Cancer Center Sloan-kettering
関連論文
- A Simple Synthesis of 1,3-Dialkylpyrido [2,3-d] pyrimidines
- Some Novel Reactions of 1,3-Dimethyluracils. II. Studies on New Stable Pyrimidine Ring-Opened Compounds
- Photochemical Synthesis of Fused Tricyclic Compounds from Bis-6,6'-(1,3-dialkyluracilyl) sulfides
- Nucleosides. CXLVIII. : Synthesis of 6-(β-D-Ribofuranosyl)picolinamide. : A Novel C-Nucleoside from D-Ribonolactone
- Nucleosides. CXLIV. Some Reactions of 2'-O-Triflyl-2,3'-anhydroxylosyluracil with Nucleophilic Reagents. Synthesis of 2'-Chloro-2',3'-dideoxyuridinene. Studies Directed toward the Synthesis of 2'-Deoxy-2'-substituted arabino Nucleosides.(5)(Organic,Chemic
- Nucleosides. CXLIII. Synthesis of 5'-Deoxy-5'-substituted-2,2'-anhydro-1-(β-D-arabinofuranosyl)uracils. A New 2,5'- to 2,2'-Anhydronucleoside Transformation. Studies Directed toward the Synthesis of 2'-Deoxy-2'-substituted arabino Nucleosides.(4)(Organic,
- Nucleosides. XXII. Synthesis of 1-(3'-Amino-3'-deoxy-β-D-glucopyranosyl) pyrimidines
- Structural Elucidation of Tubercidin
- Potential Antimetabolites. VI. An Improved Synthesis of 2-β-D-Ribofuranosyl-as-triazine-3,5 (2H, 4H)-dione (6-Azauridine).
- Potential Antimetabolites. II. Chemical Synthesis of 6-Azacytidine.
- Potential Antimetabolites. I. Selective Thiation of Uracil and 1,2,4-Triazine-3,5 (2H, 4H)-dione (6-Azauracil).
- Debenzylation Reaction of Benzylphosphoric Acid Esters
- ψ-Cytidineの合成