A Series of Novel Acyclic Nucleosides. IV. Synthesis of N^1-Sulfur Analogues of Acyclovir, Directed toward Improved Antivial Activities

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概要

• 論文の詳細を見る

• Novel imidazothiazine acyclic nucleoside analogues (9a-d, 12a-d and 3c, d) in which N^1 of the purine base is replaced by a sulfur atom were synthesized. 5-Substituted imidazo[4,5-d][1,3]thiazine-7(3H)-thiones (7a-d) were prepared from 5(4)-substituted amino-4(5)-ethoxycarbonyl-1(3H)-imidazoles with Lawesson reagent and then 7a-d were alkylated with 2-oxa-1,4-butanediol diacetate or with 2-acetoxyethoxymethyl halide to give 9a-d and 10a, d in moderate yields. Compounds 9a-d were led to the corresponding 7-one derivatives (12a-d) by KMnO_4 oxidation. Deprotection of the acetyl group in 9a-d and 12c, d was achieved by means of the Zemplen procedure.

• 社団法人日本薬学会の論文
• 1991-04-25

著者

• 松本 広淳

  Research Laboratory, Minophagen Pharmaceutical Co.,

• 森 武雄

  Research Laboratory, Minophagen Pharmaceutical Co.,

• 水野 義久

  School Of Pharmaceutical Sciences Kitasato University

• 水野 義久

  北海道大学 薬

• 原 純子

  Research Laboratory Minophagen Pharmaceutical Co.

• 金子 千里

  Research Laboratory, Minophagen Pharmaceutical Co.,

• 竹内 惟雄

  Research Laboratory, Minophagen Pharmaceutical Co.,

• 池田 一芳

  The Center for Instrumental Analysis of Hokkaido University

• 水野 義久

  Research Laboratory, Minophagen Pharmaceutical Co.,

• 森 武雄

  Research Laboratory Minophagen Pharmaceutical Co.

• 松本 広淳

  Research Laboratory Minophagen Pharmaceutical Co.

• 竹内 惟雄

  Research Laboratory Minophagen Pharmaceutical Co.

• 金子 千里

  Research Laboratory Minophagen Pharmaceutical Co.

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