Studies on Pyridazines. XXV. The Ring-opening Reactions of N-Methoxypyridazinium Salts with Nucleophiles

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概要

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• The reaction of 1-methoxypyridazinium methosulfate (1) with cyanide ion resulted in the ring fission and subsequent elimination of N_2 to give the cyano substituted vinyl acetylenes (2 and 3) and 1,3-butadienes (4). On the other hand, reactions of the salt (1) with hydroxide and dicyanomethyl anion resulted in the similar ring-opening, followed by elimination of the methoxyl group, to give vinyl diazomethanes (6 and 9), which were easily converted into the corresponding pyrazole derivatives (7 and 10) by an intramolecular 1,3-dipolar cycloaddition. The reaction mechanism is also discussed.

• 社団法人日本薬学会の論文
• 1975-11-25

著者

• 土屋 隆

  School of Pharmacy, Hokuriku University

• 井下田 浩

  School Of Pharmaceutical Sciences Showa University

• 土屋 隆

  Faculty Of Pharmaceutical Sciences Hokuriku University

• 金子 千里

  School of Pharmaceutical Sciences, Showa University

• 金子 千里

  Research Laboratory, Minophagen Pharmaceutical Co.,

• 金子 千里

  Research Laboratory Minophagen Pharmaceutical Co.

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