Studies on Diazepines. XXI. Photochemical Synthesis of 1H-2,4-Benzodiazepines from 4-Azidoisoquinolines

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概要

• 論文の詳細を見る

• Irradiation of 4-azidoisoquinolines (1a-e) in the presence of sodium methoxide resulted in ring-expansion to give 5-methoxy-1H-2,4-benzodiazepines (10) : the structures of the products were confirmed by the following chemical studies as well as spectral analyses. Treatment of the diazepines (10) with hydrochloric acid or acidic alumina in methanol resulted in ring-contraction to afford 1-aminoisoindolenines (14), and treatment with acetic anhydride gave the ring-opened products (16). The diazepines (10) were also converted to 1-methoxyisoindolenines (19) by further irradiation and to the diazepin-3-one (21) by treatment with either mesitylnitrile oxide or lead tetraacetate.

• 社団法人日本薬学会の論文
• 1985-10-25

著者

• 沢西 啓之

  Faculty Of Pharmaceutical Sciences Hokuriku University

• 沢西 啓之

  School of Pharmacy, Hokuriku University

• 土屋 隆

  School of Pharmacy, Hokuriku University

• 指田 春喜

  School of Pharmacy, Hokuriku University

• 指田 春喜

  北陸大学薬学部

• 指田 春喜

  Faculty Of Pharmaceutical Sciences Hokuriku University

• 土屋 隆

  Faculty Of Pharmaceutical Sciences Hokuriku University

• 指田 春喜

  北陸大 薬

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