Studies on Pyridazines. XVIII. Cyanation of 3,3'-Bipyridazines and Their N-Oxides via Their Quaternary Salts

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概要

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• The reaction of quaternary salts of 3,3'-bipyridazines and their N-oxides with cyanide ion was carried out. 3,3'-Bipyridazine 1,1'-dioxides (I, II) gave the dihydro compounds having cyano groups at α-positions to the N-oxide groups (IV, V). The bipyridazines without N-oxide groups (VII, VIII) afforded the dihydro compounds having cyano groups at γ-positions to the N-CH_3 groups (X, XI). And 6,6'-dimethoxy-3,3'-bipyridazine (IX) afforded 1,1'-dimethyl-3,3'-bipyridazine-6,6'(1H, 1'H)-dione (XII). As for the 2,2'-dioxide (III), the compound composed of both the dihydro type ring and the aromatic ring formed by the elimination of the methoxy group (VI), was obtained.

• 社団法人日本薬学会の論文
• 1971-07-25

著者

• 井下 田浩

  School of Pharmaceutical Sciences, Showa University

• 土屋 隆

  Faculty of Pharmaceutical Sciences, Hokuriku University

• 土屋 隆

  School of Pharmacy, Hokuriku University

• 井下 田浩

  School Of Pharmaceutical Sciences Showa University

• 奥田 千里

  School of Pharmaceutical Sciences, Showa University

• 横川 秀晴

  School of Pharmaceutical Sciences, Showa University

• 奥田 千里

  School Of Pharmaceutical Sciences Showa University

• 横川 秀晴

  School Of Pharmaceutical Sciences Showa University

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