Photochemistry. II. Formation of Methyl Paraconates and Dimethyl Succinates from Pyridazines

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概要

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• Irradiation of 6-chloro-3(2H) pyridazones (I), maleic hydrazides (IV), and 3,6-dichloropyridazines (V and VI) in methanol containing HCl, afforded γ-lactones, methyl paraconates (II), and dimethyl succinates (III). A shot time irradiation of 3,6-dichloropyridazines (V) resulted in the formation of methylated pyridazines (VI and VII), hydroxymethylated pyridazines (VIII), and methylated pyridazones (IX), along with the γ-lactones (II) and the succinates (III). The mechanism of the formation of the γ-lactones and the succinates was also discussed.

• 公益社団法人日本薬学会の論文
• 1971-06-25

著者

• 井下田 浩

  School of Pharmaceutical Sciences, Showa University

• 土屋 隆

  Faculty of Pharmaceutical Sciences, Hokuriku University

• 土屋 隆

  School of Pharmacy, Hokuriku University

• 新井 平八郎

  School of Pharmaceutical Sciences, Showa University

• 新井 平八郎

  Central Research Laboratories Zeria Pharmaceutical Co. Ltd.

• 井下田 浩

  School Of Pharmaceutical Sciences Showa University

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