Photochemistry. XI. Photochemical Ring Contraction of 3 (2H)-Pyridazinones to 1-Amino-Δ^3-pyrrolin-2-ones

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概要

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• Irradiation of 3 (2H)-pyridazinone (1a-f) in methanol afforded 1-amino-5-methoxy-Δ^3-pyrrolin-2-one (2) and 1-methyleneimino-5-methoxy-Δ^3-pyrrolin-2-one (3) by novel type ring contraction. Irradiation of them in EtOH or in the presence of Et_2NH gave 5-ethoxy- or 5-diethylaminopyrrolinone, respectively. Similarly, N-methyl-3 (2H)-pyridazinone (7) gave N-methylamino-pyrrolinone (8). Some reactions of these compounds were carried out and the mechanism of the photochemical ring contraction was also discussed.

• 社団法人日本薬学会の論文
• 1974-10-25

著者

• 井下田 浩

  School of Pharmaceutical Sciences, Showa University

• 新井 平八郎

  Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.,

• 土屋 隆

  School of Pharmacy, Hokuriku University

• 新井 平八郎

  School of Pharmaceutical Sciences, Showa University

• 新井 平八郎

  Central Research Laboratories Zeria Pharmaceutical Co. Ltd.

• 井下田 浩

  School Of Pharmaceutical Sciences Showa University

• 土屋 隆

  Faculty Of Pharmaceutical Sciences Hokuriku University

• 長谷部 正人

  School of Pharmaceutical Sciences, Showa University

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