Photochemistry. VI. Photo-induced Methylation of Pyridazines

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概要

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• Irradiation of Pyridazine (Ia) in methanol containing 5% HCl, afforded 4-methylated and 4,5-dimethylated compounds. 3-Methylpyridazine (Ib) gave 4-methylated compound, along with 5-methylated and 4,5-dimethylated compounds. 3-Methoxy-pyridazine (Ic) afforded 4-methylated and 4,6-dimethylated compounds. 3,6-Dimethylpyridazine (Ie) gave 4-methylated and 4,5-dimethylated compounds. 3-Methoxy-6-methylpyridazine (If) gave 4-methylated compound as a sole product. 3-Methyl-6-chloropyridazine (Ig), 3,6-dichloropyridazine (Ih), and 3-phenyl-6-chloropyridazine (Ii) afforded 5-methylated and 4,5-dimethylated compounds, respectively. 3-Chloropyridazine (Id) did not give monomethylated, but 4,5-dimethylated compound in a low yield of 1-2%, presumably due to the unstability and the decomposition of the starting material.

• 社団法人日本薬学会の論文
• 1972-02-25

著者

• 井下田 浩

  School of Pharmaceutical Sciences, Showa University

• 新井 平八郎

  Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.,

• 土屋 隆

  Faculty of Pharmaceutical Sciences, Hokuriku University

• 土屋 隆

  School of Pharmacy, Hokuriku University

• 新井 平八郎

  School of Pharmaceutical Sciences, Showa University

• 新井 平八郎

  Central Research Laboratories Zeria Pharmaceutical Co. Ltd.

• 井下田 浩

  School Of Pharmaceutical Sciences Showa University

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