Studies on Diazepines. XIX. Photochemical Synthesis of 2,3-Benzodiazepines from Isoquinoline N-Imides

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• The photolysis of the isoquinoline N-imides (12a-g) under basic conditions gave the corresponding 5H-2,3-benzodiazepines (13), presumably via the 1H-2,3-benzodiazepines (17), together with the parent isoquinolines (14), whereas irradiation of these N-imides (12) under neutral conditions gave no diazepines. Treatment of the 1-methyl-5H-diazepines (13b, f) with acetic anhydride gave the 3-acetyl-3H-2,3-benzodiazepines (18), which reverted back to the 5H-diazepines (13) on hydrolysis. However, the 1-unsubstituted 5H-diazepines showed no such conversion. Some reactions of the 5H-diazepines (13) thus obtained were also examined.

• 公益社団法人日本薬学会の論文
• 1982-10-25

著者

• 土屋 隆

  School of Pharmacy, Hokuriku University

• 円角 美智子

  School of Pharmacy, Hokuriku University

• 栗田 城治

  School of Pharmacy, Hokuriku University

• 栗田 城治

  Faculty of Pharmaceutical Sciences, Hokuriku University

• 土屋 隆

  Faculty Of Pharmaceutical Sciences Hokuriku University

• 栗田 城治

  Faculty Of Pharmaceutical Sciences Hokuriku University

• 円角 美智子

  School Of Pharmacy Hokuriku University

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