Studies Directed toward the Total Synthesis of Sinefungin. I. Synthesis of 4-(5'-Deoxyuridin-5'-yl)-4-nitrobutyronitrile, 4-(5'-Deoxyadenosin-5'-yl)-4-nitrobutyramide and Closely Related Nucleosides
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概要
- 論文の詳細を見る
S-Adenosylhomocysteine analogues, 1-(5,6-dideoxy-6-nitro-β-D-ribo-hexofuranosyl) uracil (7a), 9-(5,6-dideoxy-6-nitro-β-D-ribo-hexofuranosyl) adenine (7b), 4-(5'-deoxyuridin-5'-yl)-4-nitrobutyronitrile (15) and 4-(5'-deoxyadenosin-5'-yl)-4-nitrobutyramide (20) were synthesized as potential inhibitors of S-adenosylmethionine (SAM)-dependent methyltransferases and S-adenosylhomocysteine hydrolases. The chemistry developed for the preparation of these compounds should be useful in the total synthesis of the nucleoside antibiotics sinefungin and A9145C, which are potent inhibitors of certain SAM-dependent methyltransferases.
- 社団法人日本薬学会の論文
- 1984-08-25
著者
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水野 義久
School Of Pharmaceutical Sciences Kitasato University
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水野 義久
Faculty Of Pharmacy Kanazawa University
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水野 義久
北海道大学 薬
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土田 清美
Faculty of Pharmaceutical Sciences, Hokkaido University
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土田 清美
Faculty Of Pharmaceutical Sciences Hokkaido University
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