Syntheses of Potential Antimetabolites. XX. Syntheses of 5-Carbomethoxymethyl-and 5-Methylaminomethyl-2-thiouridine (The "First Letters"of Some Anticodons) and Closely Related Nucleosides from Uridine

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概要

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• A procedure for the preparation of 5-substituted 2-thiouridines from uridine has been developed, whereby 5-carbomethoxymethyl-(8b) and 5-methylaminomethyl-2-thiouridine (10) (each may be the first letter of certain anticodons of some transfer ribonucleic acids) and the closely related nucleosides [e.g., 5-hydroxymethyl-2-thiouridine (11), 5-cyanomethyl-2-thiouridine (6b), and 5-carbomethoxymethyluridine (8b)] were prepared in satisfactory yields. Acylation of 5-methylaminomethyl-2-thiouridine (10) was also examined and 5-(N-methylbenzamido) methyl-2-thiouridines (12) was prepared and characterized.

• 社団法人日本薬学会の論文
• 1975-11-25

著者

• 水野 義久

  School Of Pharmaceutical Sciences Kitasato University

• 水野 義久

  Faculty Of Pharmacy Kanazawa University

• 水野 義久

  北海道大学 薬

• 池田 一芳

  The Center for Instrumental Analysis of Hokkaido University

• 池田 一芳

  Faculty of Pharmaceutical Sciences, Hokkaido University

• 田中 澄夫

  Faculty of Pharmaceutical Sciences, Hokkaido University

• 田中 澄夫

  Faculty Of Pharmaceutical Sciences Hokkaido University

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