An Improved Synthesis of N-Hydroxyamino Acids and Their Esters Using (Z)-2-Furaldehyde Oxime
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概要
- 論文の詳細を見る
A series of N-hydroxyamino acids and their esters (9a, b, d-k) coupled with N-hydroxyglycinamide (9c) were synthesized through facile preparations of N-furfurylidenealkoxy (and hydroxy) carbonylalkylamine N-oxides (7a, b, d-g) and N-furfurylidenecarbamoylmethylamine N-oxide (7c) followed by hydrolysis. The method was applied to the syntheses of emimycin (1) and hadacidin monosodium salt (2b).
- 公益社団法人日本薬学会の論文
- 1986-08-25
著者
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三木 卓一
Department of Toxicology, Faculty of Pharmaceutical Sciences, Setsunan University
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後藤 義一
Central Research Division, Takeda Chemical Industries, Ltd.
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奥谷 哲也
Central Research Division, Takeda Chemical Ind., Ltd.,
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三木 卓一
Faculty of Pharmaceutical Sciences, Setsunan University
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後藤 義一
武田薬品工業(株)中央研究所
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奥谷 哲也
Central Research Division Takeda Chemical Industries Ltd.
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三木 卓一
Department Of Toxicology Faculty Of Pharmaceutical Sciences Setsunan University
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川喜多 健二
Central Research Division, Takeda Chemical Industries, Ltd.,
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川喜多 健二
Central Research Division Takeda Chemical Industries Ltd.
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三木 卓一
武田薬品工業株式会社研究開発本部
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Miki Takuichi
Department Of Toxicology Faculty Of Pharmaceutical Sciences Setsunan University
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