Enhancement of the Anti-tumor Activity of Recombinant Interleukin-2 (rIL-2) by Immunocomplexing with an F (ab')_2 Fragment of Murine Monoclonal Antibody against rIL-2
スポンサーリンク
概要
- 論文の詳細を見る
We have investigated the biological properties of an immune complex composed of recombinant interleukin-2 (rIL-2) and an F (ab')_2 fragment of a monoclonal antibody against rIL-2 in mice for the induction of killer cells and anti-tumor activity, as well as the pharmacokinetic properties of the immune complex injected subcutaneous-ly into mice. The immune complex demonstrated sustained serum rIL-2 levels, with a 2.4-times longer"mean-residence-time"than free rIL-2. A more significant portion of rIL-2 was detected in lymph nodes after the subcutaneous injection of the immune complex than with rIL-2 alone. Splenic lymphocytes from mice given the immune complex showed higher killer cell activity against YAC-1 and P815 cells than those from mice given rIL-2 alone. The immune complex also exerted a more significant anti-tumor effect in a dose-dependent manner in Meth-A fibrosarcoma-bearing mice than dit rIL-2 alone.
- 社団法人日本薬学会の論文
- 1994-08-15
著者
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戸口 始
Dds Research Laboratories Pharmaceutical Research Division Takeda Chemical Industries Ltd.
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佐藤 純
Dds Research Laboratories Takeda Chemical Industries Ltd.
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後藤 和徳
Pharmaceutical Research Laboratories Iii Pharmaceutical Research Division Takeda Chemical Industries
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浜口 直
DDS Research Laboratories Pharmaceutical Research Division, Takeda Chemical Industries, Ltd.
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道券 一浩
DDS Research Laboratories Pharmaceutical Research Division, Takeda Chemical Industries, Ltd.
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大津 紘一郎
Pharmaceutical Research Laboratories III Pharmaceutical Research Division, Takeda Chemical Industrie
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岩佐 進
DDS Research Laboratories Pharmaceutical Research Division, Takeda Chemical Industries, Ltd.
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小川 泰亮
DDS Research Laboratories Pharmaceutical Research Division, Takeda Chemical Industries, Ltd.
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小川 泰亮
武田薬品工業(株)dds研究所
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小川 泰亮
武田薬品工業株式会社dds研究所
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岩佐 進
武田薬品工業・DDS研究所
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大津 紘一郎
Pharmaceutical Research Laboratories Iii Takeda Chemical Industries Ltd.
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浜口 直
Dds Research Laboratories Pharmaceutical Research Division Takeda Chemical Industries Ltd.
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道券 一浩
Dds Research Laboratories Pharmaceutical Research Division Takeda Chemical Industries Ltd.
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