A New Technique to Efficiently Entrap Leuprolide Acetate into Microcapsules of Polylactic Acid or Copoly(Lactic/Glycolic) Acid
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概要
- 論文の詳細を見る
The aim of this work was to develop injectable microcapsules containing leuprolide acetate, that would deliver that drug at a zero-order rate over a period of about one month. A large amount of leuprolide acetate, a hydrophilic drug, was entrapped into polylactic aicd (PLA) and copoly-(lactic/glycolic) acid (PLGA) microcapsules prepared by an in-water dring method using a (w/o)/w emulsion. The basic techniques were designed to increase the viwcosities of the inner water phase and w/o emulsion. Under the conditions used, it was possible for the drug to be completely entrapped by the microcapsules in the range of 10 to 20% on the basis of the polymer. However, the release profiles of the drug in vitro were inadequate for controlled release for one month.
- 社団法人日本薬学会の論文
- 1988-03-25
著者
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島本 次雄
Pharmaceutics Research Laboratories Research And Development Division Takeda Chemical Industries Ltd
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岡田 弘晃
武田薬品工業株式会社 製剤研究所
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小川 泰亮
武田薬品工業株式会社 DDS研究所
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矢敷 孝司
Pharmaceutics Research Laboratories Research And Development Division Takeda Chemical Industries Ltd
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岡田 弘晃
武田薬品工業
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小川 泰亮
Pharmaceutics Research Laboratories, Research and Development Division, Takeda Chemical Industries,
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山本 真樹
Pharmaceutical Development Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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岡田 弘晃
Pharmaceutical Development Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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小川 泰亮
武田薬品工業(株)dds研究所
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小川 泰亮
武田薬品工業株式会社dds研究所
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山本 眞樹
武田薬品工業 研究開発本部 製剤研究所
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山本 真樹
武田薬品工業(株)
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