安定性研究のための人工気象室

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A newly designed laboratory for stability studies, "Artificial Climate Laboratory, " having an ability to reproduce an actual climate or any desirable climate conditions, was established. The temperature and humidity in this laboratory were controlled by the following processes : The climate data to be reproduced, i.e., the temperature and the dew point calculated from the actual temperature and relative humidity using a programmable computer, Deck Linc 8,were punched in a paper tape, a tape reader picked them up periodically, and the controlling devices sent a signal for operating the heat exchange valve and the humidifying valve simultanuously, and the temperature and humidity in each room of the laboratory were controlled full-automatically by the given data. The three actual climate conditions simulated in this laboratory were as follows : (1) A summer climate in Japan, measured in the company storehouse in Osaka, (2) a winter climate in Japan, measured by the meteorological observatory in Sapporo, and (3) a tropical climate, reported by the meteorological observatory in Bangkok, Thailand. Examinations were made on the stalility of retinol, thiamine, and ascorbic acid in a multivitamin liquid preparation, and changes in the appearance and consistency of cosmetic creams. The actual shelf-lives of the former, governed by the Arrhenius relation, agreed with that of the corresponding artificial climate condition. Therefore it was evidenced that the artificial climate well simulated the actual climate thermally. The changes of the latter, not following the Arrhenius relation, were hardly presumed by conventional accelerating method, but, nor repeating the Osaka condition of this system, changes to be expected for 1 or 1.5 years under actual climate were able to be reproduced in several months.
公益社団法人日本薬学会の論文
1975-12-25

安定性研究のための人工気象室

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