Interaction of Methyl p-Hydroxybenzoate with Polyoxyethylene Dodecyl Ethers

概要

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The interaction of methyl p-hydroxybenzoate (MP) with polyoxyethylene dodecyl ethers having a variety of numbers of oxyethylene units in the homogeneous chain was investigated by ultrafiltration and nuclear magnetic resonance spectrometry. The results obtained suggested the existence of two kinds of interaction mechanisms between the preservative and the nonionic surfactant micelle. The binding parameters in each class were calculated using a multiple regression technique. In the primary class of sites, the interaction obeyed the form of the Langmuir type adsorption and the bound molecules of MP were probably located at the interface of the hydrocarbon core and the polyoxyethylene mantle of the micelles. Moreover, in the second class of sites, the interaction could be described as a simple partition between the micelles and the aqueous phase and the preservative molecules seemed to be situated in the polyoxyethylene mantle.
公益社団法人日本薬学会の論文
1975-12-25