Studies on the Metabolic Fate and the Pharmacokinetics of 5-n-Butyl-1-cyclohexyl-2,4,6-trioxoperhydropyrimidine (BCP) in Man. I. Identification of the Metabolites of BCP in Human Urine

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概要

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• Urinary metabolites of a non-steroidal anti-inflammatory drug, 5-n-butyl-1-cyclohexyl-2,4,6-trioxoperhydropyrimidine (BCP) were investigated in man. Tow hydroxylated compounds, 1-cyclohexyl-5-(3-hydroxybutyl)-2,4,6-trioxoperhydropyrimidine (II) and 5-n-butyl-1-(4-hydroxycyclohexyl)-2,4,6-trioxoperhydropyrimidine (IV) were identified as the metabolites besides unchanged BCP, though two unknown minor peaks were observed by gas-liquid chromatography. The glucuronides or sulfates of II and IV were not detected clearly.

• 社団法人日本薬学会の論文
• 1971-03-25

著者

• 美間 博之

  Research and Development Division, Takeda Chem. Ind., Ltd.

• 美間 博之

  Research And Development Division Takeda Chem. Ind. Ltd.

• 矢敷 孝司

  Pharmaceutics Research Laboratories Research And Development Division Takeda Chemical Industries Ltd

• 千田 重男

  Gifu College of Pharmacy

• 和泉 弘

  Gifu Women's Junior College

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