Pyrimidine Derivatives and Related Compounds. XXXIII. Reactions of 6-Bromomethyl-5-formyl-1,3-dimethyluracil and Its Hydrazones with Nucleophiles. Synthesis of Pyrrolo [3,4-d] pyrimidines and Pyrimido [4,5-d] pyridazines

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概要

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• The reactions of 6-bromomethyl-5-formyl-1,3-dimethyluracil (1) and its hydrazones (6a and 6b) with nucleophiles were investigated. Treatment of 1 with primary amines or hydrazines afforded pyrrolo [3,4-d] pyrimidines or pyrimido [4,5-d] pyridazines, respectively. When 6-bromomethyl-1,3-dimethyluracil-5-carboxaldehyde tosylhydrazone (6a) was treated with hydrazine hydrate, it was readily converted into pyrrolo [3,4-d] pyrimidine (7) and pyrimido [4,5-d] pyridazine (8). The reaction of 6-bromomethyl-1,3-dimethyluracil-5-carboxaldehyde acetylhydrazone (6b) with hydrazine hydrate gave N-aminopyrrolo [3,4-d] pyrimidine (9).

• 社団法人日本薬学会の論文
• 1981-06-25

著者

• 千田 重男

  Gifu College of Pharmacy

• 広田 耕作

  Gifu Pharmaceutical University

• 浅尾 哲次

  Gifu College of Pharmacy

• 山田 喜広

  Gifu College of Pharmacy

関連論文

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