Pyrimidine Derivatives and Related Compounds. XL. Synthesis of 7-Substituted Pyrimido [5,4-d] pyrimidines
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概要
- 論文の詳細を見る
5-Amino-1,3-dimethyl-6-(substituted amino) methyluracils (3a-d) prepared by the reduction of 1,3-dimethyl-5-nitro-6-(substituted amino) methyluracils (2a-d) were treated with triethyl orthoformate to give the corresponding 7-substituted pyrimido [5,4-d] pyrimidines (7a-d) in good yields. Treatment of 3a with dimethylformamide dimethyl acetal afforded a 5-dimethylaminomethylenamino intermediate (6), which cyclized to 7a on heating in toluene.
- 社団法人日本薬学会の論文
- 1981-10-25
著者
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千田 重男
Gifu College of Pharmacy
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広田 耕作
Gifu Pharmaceutical University
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北出 幸夫
Gifu Pharmaceutical University
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北出 幸夫
Department Of Medicinal Chemistry Gifu Pharmaceutical University
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浅尾 哲次
Gifu College of Pharmacy
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山田 喜広
Gifu College of Pharmacy
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