Studies on the Metabolic Fate and the Pharmacokinetics of 5-n-Butyl-1-cyclohexyl-2,4,6-trioxoperhydropyrimidine (BCP) in Man. II. Determination of BCP and Its Metabolite, 1-Cyclohexyl-5-(3-hydroxybutyl)-2,4,6-trioxoperhydropyrimidine by Ultraviolet Absorp
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概要
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The determination-procedures of BCP and its urinary metabolites, 1-cyclohexyl-5-(3-hydroxybutyl)-2,4,6-trioxoperhydropyrimidine (II) and 5-n-butyl-1-(4-hydroxycyclohexyl)-2,4,6-trioxoperhydropyrimidine (IV) were investigated by ultraviolet absorption method. Total and free BCP in a urine were determined separately by changing the conditions for extraction. The metabolite II in a urine was determined selectively by converting it to 3-cyclohexyl-7-methyl-1,2,3,4,6,7-hexahydro-5-H-pyrano (2,3-d) pyrimidine-2,4-dione (XV), though IV was not determined by this method as the separation from the unknown metabolites was not successful.
- 社団法人日本薬学会の論文
- 1971-03-25
著者
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美間 博之
Research and Development Division, Takeda Chem. Ind., Ltd.
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美間 博之
Research And Development Division Takeda Chem. Ind. Ltd.
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矢敷 孝司
Pharmaceutics Research Laboratories Research And Development Division Takeda Chemical Industries Ltd
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矢敷 孝司
Research and Development Division, Takeda Chem. Ind., Ltd.
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近藤 貴雄
Research and Development Division, Takeda Chem. Ind., Ltd.
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宇田 良明
Research and Development Division, Takeda Chem. Ind., Ltd.
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